Animals:
42 albino Swiss mice (20-22 g) of either sex.
dose and duration of treatment: 40,
60 and 80 mg/kg for 7 days per oral.
Animals were placed on the electric grid (20
V with AC current of 5 mA); the latency to
reach shock free zone [SFZ] and the mistakes (descents) the
animal made in 15 min were recorded.
Results:
showed significant decrease in the latency
to reach SFZ and in the number of mistakes
in 15 min at all the tested doses when compared
to the vehicle control.
administered at the dose of 60 mg/kg in scopolamine
treated amnesic mice showed significant decrease
in latency to reach SFZ and in the number
of mistakes in 15 min as compared to the scopolamine
control.
Animals: 42 albino Wistar rats (150-175
g) of either sex.
dose and duration of treatment: 27,
40 and 54 mg/kg for 7 days per oral.
The time spent by the animals for exploration
(directing nose at a distance < 2 cm to
the object or touching it with nose) of the
familiar (F) and new (N) objects were recorded
and Discrimination Index (D) = N-F / N+F.
Results:
showed a significant increase in the discrimination
index at all the tested doses when compared
to the vehicle control.
administered at the dose of 40 mg/kg in scopolamine
treated amnesic rats showed significant increase
in the discrimination index as compared to
the scopolamine control.
3. Nootropic activity of
using elevated plus maze test in mice
Animals:
42 albino Swiss mice (20-22 g) of either
sex
dose
and duration of treatment: 40, 60 and
80 mg/kg for 7 days per oral.
Transfer Latency (TL) [the
time taken by the mouse to move into the
enclosed arm of the elevated plus maze]
was measured and expressed as inflexion
ratio = [initial TL-TL after 24 h / TL
after 24 h]
Results:
A significant decrease in the inflexion
ratio was noticed in the scopolamine treated
group as compared to the vehicle control.
administered at the dose of 60
mg/kg in scopolamine treated amnesic mice showed
significant increase in the inflexion
ratio as compared to the scopolamine control.
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